Diagnosis and Management of New-Onset Central Diabetes Insipidus in Critically Ill Children Varies Between Pediatric Critical Care Medicine and Pediatric Endocrinology Clinicians

Authors

R. Brandon Hunter, Division of Critical Care Medicine, Texas Children’s Hospital, Houston, TXFollow
Herodes Guzman, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA
Jessica Winters, Division of Critical Care, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL
Katherine Lord, Division of Endocrinology and Diabetes, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Matthew Kirschen, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA; Department of Anesthesiology and Critical Care Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA; Departments of Anesthesiology, Critical Care and Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Vijay Srinivasan, Department of Pediatrics, Children’s Hospital of Philadelphia, Philadelphia, PA; Department of Anesthesiology and Critical Care Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA; Departments of Anesthesiology, Critical Care and Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA

Abstract

Introduction: The diagnosis and management of central diabetes insipidus in critically ill children is not standardized. Our objective was to characterize differences between Pediatric Critical Care Medicine (PCCM) and Pediatric Endocrinology (PE) clinicians in diagnosis and management of new-onset CDI in the pediatric intensive care unit. We also sought to characterize knowledge gaps among general pediatrics (GP) residents. Materials and Methods: A scenario-based survey to assess patterns of diagnosis and management of new-onset CDI that was distributed to PCCM, PE and GP clinicians who work in a quaternary care urban children’s hospital. Results: Of 275 PCCM, PE and GP clinicians surveyed, 158 (57%) responded. More PCCM clinicians than PE clinicians relied on serum sodium levels (96% vs 75%, p<0.01) and more PE than PCCM clinicians relied on serum osmolality (91% vs 40%, p<.001) for diagnosis. Fewer PCCM than PE clinicians favored restricting IV fluids to 2/3 maintenance rate (4% vs 37%, p<0.001). More PCCM clinicians than PE clinicians favored a starting dose of 0.5 milli-units/kg/hr for IV vasopressin infusion (76% vs 53%, p=0.048). More PCCM clinicians than PE clinicians favored titrating the IV vasopressin infusion every 20 minutes (24% vs 2%, p=0.02), whereas more PE clinicians than PCCM clinicians favored titration every 60 minutes (38% vs 14%, p=0.03). GP residents earlier in training had greater self-reported gaps in knowledge. Conclusions: We observed substantial variability in the diagnosis and management of new-onset CDI in critically ill children among PCCM, PE, and GP clinicians. There is a need for greater standardization in care of these patients.

Recommended Citation

Hunter, R. Brandon; Guzman, Herodes; Winters, Jessica; Lord, Katherine; Kirschen, Matthew; and Srinivasan, Vijay (2025) "Diagnosis and Management of New-Onset Central Diabetes Insipidus in Critically Ill Children Varies Between Pediatric Critical Care Medicine and Pediatric Endocrinology Clinicians," Journal of Pediatric Intensive Care: Vol. 14: Iss. 2, Article 10.
DOI: https://doi.org/10.53391/2146-4618.1031
Available at: https://jpic.researchcommons.org/journal/vol14/iss2/10